Collagen biostimulators have transformed aesthetic medicine by delivering progressive, long-lasting results. Rather than filling, they stimulate your body to produce new collagen. But not all biostimulators work the same way. Here we compare the three most widely used: Sculptra, Radiesse, and Profhilo.
Mechanism of Action
- Sculptra (poly-L-lactic acid / PLLA): triggers a controlled inflammatory response that stimulates the production of type I collagen gradually. Results develop progressively over several months.
- Radiesse (calcium hydroxylapatite / CaHA): provides an immediate filling effect thanks to its CaHA microspheres, while simultaneously stimulating collagen and elastin production in the following weeks.
- Profhilo (stabilized high-concentration hyaluronic acid): not a conventional filler. It distributes evenly beneath the skin to stimulate collagen, elastin, and deep hydration, improving overall skin quality.
Results and Duration
- Sculptra: results begin to show from the second month and develop fully between 3 and 6 months. The effect can last up to 2 years. Typically 2 to 3 sessions are needed, spaced 4 to 6 weeks apart.
- Radiesse: offers immediate improvement (filling effect) plus progressive biostimulation results. Duration approximately 12 to 18 months. Generally 1 to 2 sessions are required.
- Profhilo: improves skin luminosity and elasticity within a few weeks. Applied in 2 sessions separated by one month, with results lasting approximately 6 months. Ideal as a maintenance treatment.
Which Is Right for You?
The choice depends on your goals: if you want to restore lost volume with long-lasting effects, Sculptra or Radiesse may be the best option. If your priority is improving skin quality, luminosity, and hydration, Profhilo stands out for its versatility. In many cases, a strategic combination of biostimulators delivers the most comprehensive results.
At Elyzea, Dr. Geldres analyzes your skin quality, degree of laxity, and expectations to recommend the right biostimulator — or combination — for your needs. For international patients, collagen biostimulators in Lima cost significantly less than in the US or Europe, with the same pharmaceutical-grade products and direct physician supervision. A free virtual consultation is available to plan your treatment before you travel.
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Fillers at Elyzea — product selection and placement matters
The visible difference between great filler results and disappointing ones is rarely the brand of product — it is the product selected for the specific anatomical zone and the placement technique. Hyaluronic acid fillers (Juvederm, Restylane, Belotero) come in different densities calibrated for different layers (deep cheek vs lip vs tear trough). Calcium hydroxylapatite (Radiesse) and poly-L-lactic acid (Sculptra) are biostimulators with different durability and biological response profiles. The right product for the right placement is what produces natural, anatomically appropriate results. At Elyzea, Dra. Geldres is a board-certified plastic surgeon with detailed knowledge of facial anatomy and the product behavior of each filler family — and she will recommend the product that fits your specific concern, not "the filler we have on hand."
Why Elyzea is different in Lima
International patients get bilingual care, a free virtual consultation before flying, and a full clinical facility in Miraflores — treatment room, anesthesia bay, recovery room. Plan your visit from abroad.
What the free virtual consultation covers
Before any travel, a free virtual consultation reviews your goals, candidacy and exact pricing — so you fly with a confirmed plan, not a sales pitch. Book it and plan your visit here.
Transparent pricing — no surprises
Every treatment Elyzea offers is published on our public price list (prices.md in the website repository, mirrored on the price pages). The free virtual consultation determines protocol, sessions, and any combination plan; the per-session prices on the public list are what you pay. There are no opaque "personalized quotes" that scale to perceived ability to pay, no pressure-package upsells, and no surprise invoice items at checkout.
Anesthesia tier (topical, nerve block, oral sedation, or conscious IV sedation) is matched to the protocol depth and discussed transparently at consultation. When a treatment is part of a multi-modality plan (HIFU + Morpheus8, fillers + CO₂, etc.), the full cost is mapped out before any commitment. Lima pricing reflects local cost structure — significantly below US clinics for the same FDA-cleared technology — and the public price list ensures the savings actually reach the patient.